CBD-THC Interactions: Study Finds Increased Adverse Effects for Cannabis Users

A new study led by researchers at Johns Hopkins Medicine has revealed that high doses of cannabidiol (CBD) may increase the effects of tetrahydrocannabinol (THC) in edible cannabis products, resulting in stronger, longer-lasting drug interactions. The findings suggest that users may experience increased adverse effects from THC when consuming products containing CBD.

Ryan Vandrey, professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine and the study's senior author, said, “We have demonstrated that with a relatively high oral dose of CBD [640 mg] there can be significant metabolic interactions between THC and CBD, such that the THC effects are stronger, longer-lasting, and tend to reflect an increase in unwanted adverse effects.

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